SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
نویسندگان
چکیده
منابع مشابه
synthesis and characterization of some macrocyclic schiff bases
ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولNovel Schiff Bases of Pyrrole: Synthesis, Experimental and Theoretical Characterizations, Fluorescent Properties and Molecular Docking
Some new Schiff-base compounds based on pyrrole were synthesized by the reaction of 2-amino-1-methyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile (1)with aromatic aldehydes (2a-2e) in ethanol/acetic acid at room temperature. The structures of the Schiff bases were characterized by full spectral data. The fluorescence emission intensity of the Schiff bases has bee...
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Cinchophen (I) was synthesized from pyruvic acid, aniline and benzaldehyde by Doebner synthesis. Cinchophen acid chloride (II) was synthesised from cinchophen and oxalyl chloride by acylation reaction. The 2phenylquinoline-4-carboxylic acid amide (III) was synthesized from acid chloride and ammonia by simple reaction. The 2-phenylquinoline-4-carboxylic acid amine (IV) was synthesized from cinch...
متن کاملSynthesis, Characterization and Biological Evaluation of Schiff Bases of Propanedihydrazide
A Schiff base series of malonohydrazide was synthesized by reaction of malonohydrazide with various aldehydes. Hydrazine hydrate was reacted with ethyl malonate in ethanol to give malonohydrazide in very good yields. The synthesized compounds were characterized using FTIR and NMR spectroscopies. The biological evaluation of the Schiff bases was carried against Gram +tive and Gram –tive bacteria...
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Three new rimantadine Schiff bases (RSBs) were prepared, and then the interaction of RSBs with bovine serum albumin (BSA) was investigated using fluorescence, synchronous fluorescence, UV-vis absorption spectroscopy under physiological conditions. The results showed that the three RSBs effectively quenched the intrinsic fluorescence of BSA via static quenching. Binding constant (Ka), number of ...
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ژورنال
عنوان ژورنال: Journal of the Chilean Chemical Society
سال: 2013
ISSN: 0717-9707
DOI: 10.4067/s0717-97072013000300016